Sartoguard PES | Sartoscale 47 | 0.1µm | 3pc.

The asymmetric polyether sulfone (PES) membranes used in Sartoguard PES filters achieve an LRV of 6 per cm². This significantly reduces the bioburden in the downstream process and protects subsequent purification steps. When used upstream of sterilization grade filters, Sartoguard PES increases overall throughput and reduces the number of filters required and process costs.

Main Applications

• Bioburden reduction in protein- and virus-based therapies as well as in processes producing pDNA/mRNA based therapies
• Protection of purification equipment and sterilizing-grade filters

Benefits

• More economical process flow
• Downsizing of filtration systems
• Significantly higher total throughput performance
• LRV of 6 per cm2 filtration area for Brevundimonas Diminuta (0.1 µm version) and for Serratia Marcescens (0.2 µm version)

SartoScale units are ideally suited for all types of filterability studies with the aim of selecting the optimal prefilter for an optimal application. Moreover, they can determine the ideal combination of pre- and final filters with the aid of a minimum product volume.

• Developed for the execution of reliable filterability samples
• Made from the same non-woven fabric material as the original filter cartridges
• Ready-to-use single-use test filter unit

Membrane

Sartoguard PES uses a heterogeneous double membrane made of polyethersulfone

SartoScale units contain the original filter active material of the corresponding filter cartridges to ensure the repeatability of test results.

Flexibility

Sartoguard PES filters are available in a wide range of filtration areas from 4.5 cm² up to 1.8 m² and with a variety of commonly used connections to ensure easy integration into your process regardless of batch size.

Using SartoScale during filtration studies saves time which would otherwise be used for the installation preparations for the punch piece in the stainless steel filter brackets and prevents possible installation errors.

After the material selection or the definition of a pre/final filter combination with the SartoScale units, a scale-up method should be carried out for the flow rate and total flow using pleated capsule units of small scales (e.g. capsule size 4).

SartoScale units have an extremely low residual volume for performing filterability samples with minimized product volumes.

SartoScale test filter units are equipped with suitable filter membranes for integrity testing so that their integrity can be determined using the bubble point test in order to ensure absolute reliability of the test results.

We recommend using the SartoScale units together with the Zero-T Filter Test System to make the filtration studies as effective as possible. The Zero-T system consists of hardware and software modules which make it easy to handle and install Sartoscale test filter units. Automatic data collection is achieved by connecting a frame to a laptop. The software automatically analyzes the incoming data for the scale-up calculations.