Choose your Non-viral in vivo delivery
LipidBrick® is a unique library composed of innovative proprietary imidazolium-based cationic lipids dedicated to the formulation of lipid nanoparticles (LNPs). These active lipids safeguard mRNA molecules and enhance the transfection ability of LNPs. Each LipidBrick® lipid is permanently charged; therefore, unlike ionizable lipids, it confers an overall positive charge to LNPs, which induces extra-hepatic tropism. In addition, delivery efficacy and biodistribution can be fine-tuned by screening the LipidBrick® library to select the most suitable LipidBrick® lipid for each specific application therapeutic need.
Key Benefits:
- Efficient: Modulate LNP properties to adapt biodistribution to therapeutic goals.
- Secure: Unique structure protected by an independent patent held by Polyplus (now part of Sartorius).
- Time-Saving: In vitro and in vivo proof of concept studies have been successfully performed.
- Flexible: Versatile library for selecting the best LipidBrick® for each application.
Applications
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ApplicationActive cationic lipids for LNP formulation
Biological Information
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Molecule deliveredmRNA
Chemical Information
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IUPAC/Chemical Name3-butyl-1-(2,6-dimethyl-14-octadecyldotriacontan-9-yl)-1H-imidazol-3-ium chloride.
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Linear FormulaC59H117ClN2
Compliance Information
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Product Documentation
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Protocol
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Certificate of Analysis
- Master Safety Data Sheet
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Protocol
General Specifications
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Amount of ReagentLipidBrick® Library Kit (8 x 50 mg)
Storage Conditions
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Storage Conditions-20 °C ± 5 °C