TFF Cassettes for mAb Filtration
Sartocon® Q Hydrosart® 30 kDa mAb features a stabilized cellulose membrane and Q‑Screen channel in a self‑sealing TFF cassette. It supports buffer exchange, volume reduction and target concentration steps for monoclonal antibodies with efficient mass transfer and straightforward scale‑up.
Format and Design
- Self‑sealing cassette format eliminates separate gaskets and simplifies setup.
- Enlarged feed and retentate ports help reduce pressure drop across the device.
- Silicone sealing compound is formulated for low extractables.
- Designed to integrate into TFF filter setups and ultrafiltration cassette platforms.
Membrane and Screen
- Hydrosart® stabilized cellulose membrane with a new 30 kDa molecular‑weight cutoff specifically designed for mAb processing.
- Hydrophilic, non‑protein‑binding surface supports yield and limits nonspecific adsorption.
- Low fouling tendency supports consistent operation.
- Consistent performance maintained even after multiple NaOH cleanings, ensuring reliable repeated use.
- The advanced new screen type, called Q-Screen, enables higher final antibody concentrations.
- High permeate flow enables efficient processing at both medium and high concentrations.
- This medium channel promotes mass transfer even at low feed flow for efficient throughput.
Applications
- Concentration of monoclonal antibody solutions prior to formulation.
- Ultrafiltration and diafiltration for buffer exchange and volume reduction.
- TFF process development, scale‑up, and manufacturing runs.
Advantages at a Glance
- New designed 30 kDa cutoff for consistent separation performance.
- Scalable platform from development to production with reproducible retention at a high level.
- Processing of medium and high viscocities with high flow of permeate.
- Stable flows after NaOH cleaning.
- Broad pH compatibility aligned with common bioprocess requirements.
- Simplified handling and cleaning to support efficient turnaround.