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CIMmultus® DEAE 1 mL Monolithic Column (2 μm)

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CIMmultus® DEAE 1 mL Monolithic Column (2 μm)
 

This high-performance ion exchange column is primarily intended for fast and efficient purification of biomolecules, especially for plasmid DNA, through their ionic interaction with the monolith.

GMP Compliance
Volume
Channel Size
Item No.: 
311.5114-2
Availability: 
Piece
1
*Custom/bulk order quotes are provided within 72 hours of request.

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CIMmultus® Monoliths are reusable chromatography devices for scalable high-resolution purification of complex biological samples. Inside the custom designed housing is a single piece stationary phase with homogeneous channel size and surface chemistry. This stationary phase is designed to simplify method transfer from development into production. CIMmultus® can be used as single-use disposable or multi-use columns, and they are available in various volume ranges – from 1mL for screening and method development purposes up to 40L for industrial manufacturing.

CIMmultus® DEAE is a high-performance ion exchange column, primarily intended for fast and efficient purification of biomolecules, especially for plasmid DNA, through their ionic interaction with the monolith.

DEAE features:

  • Weak anion exchanger
  • Working range, pH 2–9
  • Binds molecules with a predominantly negative charge, repels molecules with a predominantly positive charge
  • Use for capture, intermediate, or polishing steps in either bind-elute or flow-through mode

Benefits:

  • Very fast processes by convective mass transport – resolution independent of flow
  • Ready to use columns
  • High-capacity for large molecules due to fully accessible void volume in the channels
  • Laminar flow minimizes shear stress resulting in high yields

Applications

  • Application
    Preparative Applications

Compliance Information

  • GMP Compliance
    non-cGMP

Connections (Physical)

  • Connector(s)
    10-32 UNF coned port, 0.0625" OD tubing connection

Dimensions

  • Channel Size
    2 µm
  • Column Tube Length
    4.2 mm
  • Inner Diameter
    6.7 mm
  • Outer Diameter
    18.6 mm

Features

  • Reusable
    Yes

General Specifications

  • Flow Rate
    0.1–16 mL/min | 4.2–625 cm/h | 0.1–16 CV/min

Materials of Construction

  • Materials of Construction
    Poly(glycidyl methacrylate -co- ethylene dimethacrylate)

Operating Conditions

  • Maximum Operating Pressure
    1.8 MPa | 18 bar | 260 psi
  • Recommended Operating Temperature
    4 °C (39 °F) to 40 °C (104 °F)
  • pH Stability
    Working range 2–10, cleaning in place 1–14

Physicochemical Information

  • Bed Volume
    1 mL
  • Ligand
    DEAE (weak anion exchanger, diethylamino)
  • Typical Dynamic Binding Capacity 10% per mL
    ≥ 20 mg BSA/ml wet support, BSA, 1.0 mg/mL, 20 mM Tris-HCI buffer, pH 7.4, flow rate 4 mL/min

Product Information

  • Brand
    CIMmultus®
  • Package Type
    Individually Packed

Volume

  • Volume
    1 mL
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