Sartopure® GF Plus Midicaps® 1.2 µm Size 9

Sartopure^® GF Plus Midicaps^®

Sartopure^® GF Plus Midicaps^® are compact, ready-to-use capsule depth filters for clarification and prefiltration in pharmaceutical and biopharmaceutical process streams. Their enclosed capsule format is suitable for small-volume processing, process development and scale-down applications. The two-layer glass-fiber fleece supports adsorptive and mechanical reduction of colloids, lipids, protein aggregates and particles before downstream filtration or purification steps.

Main Formats:

• Retention Ratings: Available in 0.65 µm and 1.2 µm to support selection according to particulate load, feed stream composition and downstream filtration requirements.
• Midicaps^® Format: Compact capsule format for laboratory-scale, development-scale and limited-volume process applications.
• Ready-to-Use Capsule Design: Enclosed filter unit that can be integrated into small single-use filtration assemblies.
• Connector Options: Available with process-relevant connector configurations depending on selected article and application setup.

Applications:

• Small-Volume Clarification: Suitable for clarification of limited-volume pharmaceutical and biopharmaceutical process fluids.
• Process Development: Supports early-stage filtration studies and evaluation of Sartopure^® GF Plus depth filtration performance.
• Scale-Down Studies: Enables small-scale testing to support filter selection and process transfer to larger formats.
• Cell Culture Harvest Clarification: Helps reduce particles, colloids, lipids and protein aggregates in harvested cell culture fluids.
• Fermentation Broth Prefiltration: Applicable before downstream membrane filtration, chromatography or ultrafiltration steps.
• Media and Serum Filtration: Suitable for serum-containing or serum-free media and fluids with colloidal or lipid-based contaminants.
• Viscous Solution Prefiltration: Can be used for viscous ophthalmic and large-volume parenteral solutions at appropriate process scale.

Materials Used:

• Filter Medium: Two-layer glass-fiber fleece for combined adsorptive and mechanical retention.
• Support Material: Polypropylene support fleece.
• Capsule Housing: Polypropylene.
• Core and End Caps: Polypropylene.
• O-Rings: Silicone as standard, with EPDM or fluoroelastomer options depending on configuration and process requirements.
• Regulatory-Related Product Information: Non-pyrogenic according to USP Bacterial Endotoxins test and passes USP Plastic Class VI test, according to product documentation.

Advantages:

• Compact Capsule Format: Supports clarification and prefiltration where small hold-up volume and easy handling are important.
• Adsorptive Depth Filtration: The glass-fiber matrix helps reduce colloids, lipids, protein aggregates and particles in challenging process streams.
• Defined Retention Options: 0.65 µm and 1.2 µm ratings allow adaptation to different clarification needs.
• Single-Use Integration: Ready-to-use capsule design supports disposable filtration workflows and small process assemblies.
• Scale-Up Support: Midicaps^® can be used in development work to support transfer to larger Sartopure^® GF Plus capsule or cartridge formats.
• Downstream Process Protection: Helps reduce particulate and colloidal burden before membrane filters, chromatography columns and ultrafiltration systems.
• Sterilization Option: Midicaps^® can be autoclaved within specified operating limits.

Together, these features make Sartopure^® GF Plus Midicaps^® a practical format for small-scale clarification, prefiltration and process development in pharmaceutical and biopharmaceutical workflows.