CMM HyperCel resin is composed of a rigid cellulose matrix that has flow properties compatible with the needs of manufacturing scale protein production.
The proprietary ligand, containing both a primary amine and a carboxyl group, confers cation exchange and hydrophobicity properties to the chromatography resin. The flexibility of the ligand enables the separation of proteins with a large variety of isoelectric points and hydrophobicity levels, and multiple conditions can be employed to separate targeted molecules from contaminants.
CMM HyperCel pre-packed columns are designed to simplify resin screening and selection, making them ideal for optimizing process steps. The RoboColumn® format is particularly suited for high throughput process development (HTPD), allowing for efficient and streamlined purification processes.
Features and Benefits
- Unique selectivity
- High capacity mixed mode chromatography resin
- High recovery, low elution volume
- Easy CIP, NaOH stable
Applications
- Capture of mAbs, Fab fragments and recombinant proteins from challenging feedstocks
- Separation of proteins with similar isoelectric point and | or hydrophobicity at low or high conductivity
