Sartopore® 2 XLG Cartridge 10"

Sartopore® 2 XLG filter cartridge is a high-performance PES membrane filter, used in stainless steel housings, to perform sterilizing-grade filtration in bioprocesses. Its unique membrane composition boosts the filtration efficiency in downstream processing of proteins or lipid nanoparticles.

Pore Size: 0.8 µm | 0.2 µm

Filter Size
Item No.: 
5442507G1

*Custom/bulk order quotes are provided within 72 hours of request.

Sartopore® 2 XLG is a high-performance membrane filter, offering more than just reliable sterilizing-grade filtration in biopharmaceutical processes. Its highly asymmetric membrane structure and composition of 0.8µm prefilter in front of the sterilizing-grade filter (0.2 µm pore size), boosts the filtration efficiency in downstream processing of protein-based therapies or innovative drug delivery systems like lipid nanoparticles (LNPs). Thanks to the outstanding total throughput, Sartopore® 2 XLG is also a choice for filtration after the cell harvest.

The XL in its name indicates an increased effective filtration area (EFA). By using a different pleating technology, the EFAs of Sartopore ® 2 XLG filters are - depending on filter format - 30-40% higher than for the conventional Sartopore® 2 filters. This leads to higher total throughput per filter element and less filter consumption or enables the use of a smaller filter element for a process to reduce the footprint and waste.

Sartopore® 2 XLG filters are available in all established formats with different sizes and for different purposes: Conventional filter cartridges for stainless steel housings or single-use capsules like the small Capsules, the mid-sized Midicaps®, the larger Maxicaps® / T-Style Maxicaps® and the Maxicaps® MR for very large volumes (e.g, clarification after bioreactor harvest). The single-use capsules are available as pre-sterilized (by autoclaving), autoclavable or gamma irradiatable versions. The wide range of different filter formats and sizes ensures that customers can easily scale up their process during drug development process – from preclinical to commercial scale.

Focus Applications

  • Cell culture media preparation
  • Post cell harvest filtration
  • Protein-based therapies (Downstream intermediates, form & fill)
  • Lipid nanoparticles (Downstream intermediates, form & fill)

Your Benefits

  • Increased total throughput leads to less filter consumption, less process interruptions and reduced costs
  • Increased effective filtration enables the use of smaller filters to reduce footprint and waste
  • Proven and robust membrane chemistry known from the widely established Sartopore® 2 family lowers validation effort in case of process optimization
  • Broad range of formats and sizes assures scalability and enables use of Sartopore® 2 XLG along the whole drug product lifecycle: from development to commercial processes
  • Offers secure bacterial retention according to ASTM guidelines

Applications

  • Application
    8799048270432  
  • Industry
    8799054758496  

Biological Information

  • Bacterial Retention
    8798947508832  

Compliance Information

  • Bacterial Endotoxins
    8798947377760  
  • Biological Reactivity
    8804252484192  
  • Extractables
    8798986044000  

Connections (Physical)

  • Connector Inlet
    8798969660000  
  • Connector Outlet
    8798969660000  

Dimensions

  • Filter Size
    8798990860896  
  • Filtration Area
    0.8 m²  
  • Outer Diameter
    70 mm  

General Specifications

  • Capsule/Cartridge Format
    8798961861216  
  • Maximum Allowable Back Pressure
    2 bar (29 psi) at 20°C; 1 bar (14.5 psi) at 80°C  
  • Maximum Diffusion
    23 mL/min at 2.5 bar | 36 psi at 20 °C per 10 inch element  
  • Minimum Required Bubble Point
    3.2 bar | 46 psi  

Materials of Construction

  • Housing Material
    8804580328032  
  • Material o-ring | seal
    8799065703008  
  • Membrane Material
    8799043650144  
  • Support Fleece
    8799043191392  

Operating Conditions

  • Maximum Differential Pressure
    8799040963168  

Physicochemical Information

  • Non-Fiber Releasing
    8799064457824  
  • Pore Size Final-filter
    0.2 µm  
  • Pore Size Pre-filter
    0.8 µm  

Product Information

  • Brand
    8798953472608  
  • Pack Size
    1  

Sterility/Purity

  • Sterilization Method
    8799086674528  

Usage Protocols

  • Sterilization Procedures
    • In-Line Steam Sterilization: at 134 °C, 20 min., 0.5 bar, min. 25 Cycles  
    • Autoclaving: at 134°C, 30 min, 2 bar, min. 25 Cycles  
  • Liquid Filter Housings
    Item no.
    M_Liquid_Filter_Housings

    Sartorius Stedim Biotech Sanitary Single Round Filter Housings are specifically designed for liquid filtration applications of the Bio-Pharmaceutical Industry. Application: bioreactors, CIP skids, autoclaves, lyophilizers and process tanks.

  • Sartocheck® 5 Plus Filter Tester
    Item no.
    26787---FT---P

    The Sartocheck® 5 Plus Filter Tester is an automatic filter integrity tester with automated Quality Risk Management (QRM) designed to cover the complete range of integrity testing from small syringe filters up to large multi-round housings and tangential flow cassettes.

  • Sartoguard
    Item no.
    M_Sartoguard

    All members of the Sartoguard family utilize a highly asymmetric polyether sulfone (PES) membrane double layer for unmatched protection of final filters and bioburden reduction with an LRV of 6 per cm². In addition, combinations with different depth filter materials and gamma sterilizable versions are available.