Batch process modelling - Onsite course

Course Objective

The objective of this course is to guide the attendees through their journey from a process data set to a multivariate monitoring model based on their process data. Multivariate data tables are translated into interpretable charts and plots which simplifies the process monitoring as well as analysis of process deviations. Multivariate technology is the science of separating the signal from the noise in data with many variables and presenting the results in a simple graphical format. Quickly go from a complicated table of numbers to a simple plot of the essentials. The key to unlocking the information in your data lies in the correlations among the variables, not in the variables themselves.

Who should participate?

Intended for researchers, scientists and engineers from all sectors of biopharma with a lot of process understanding but with no or limited statistical background. Typical applications include product development, process improvement/optimization, investigations of deviation and scale-up of processes.

Selected Course Content

Introduction to batch methodology and modelling concept

• Raw data analysis: How to find reliable data
• Background of statistical methods applied
• Modeling of Batch evolution and Model interpretation
• Transferring models into SIMCA® online
• The course slides contains many practical hints to make modelling easy

Language Information

Seminars are given in the language stated. In-depth discussion, course material and printed material are in English hence knowledge of English is required.

Schedule

Session 1: Introduction, What is a process and aspects of Bio Processing.

• Introduction to Sartorius Data Analytics.
• Values, Objectives and Possibilities for Multivariate Batch modeling and monitoring.
• What is a process and aspects of Bio Processing.
• Basic understanding of the multivariate techniques used.
• Software click-along demo.

Session 2: PCA and OPLS

• Applications of PCA and OPLS.
• Initial considerations.
• Data organization and raw data analysis.
• Software click-along demo.

Session 3: Batch Evolution Models (BEM), Batch Level Models (BLM)

• Details of the BEM
• Details of the BLM
• Software click-along demo

Session 4: The transition from offline to online modeling

• Moving to SIMCA®-online
• Navigating in SIMCA®-online
• Model maintenance and updating
• Software click-along demo
• Course debriefing and final Q&A

Course Material and Software

The electronic course material (course slides and exercises) and the SIMCA® course license will be sent out by email two weeks before the course starts. Please install the SIMCA® software onto the laptop that you will bring with you to follow the open onsite training course. SIMCA® needs Admin rights to be installed so please arrange this with your organization’s IT and allow time for the installation to be carried out before the course commences. Sartorius cannot install SIMCA® onto your own laptops for you.

Cost and Conditions

The 2-day open onsite course fee is 1750€ per person (2025 price).

Cancellations received less than two weeks before the course will not be refunded. For courses cancelled more than two weeks before the course starts, Sartorius Stedim Data Analytics AB will retain 10% of the course fee to cover administrative costs, and the remaining amount will be refunded.

The registering company can substitute course participant(s) as long as Sartorius Stedim Data Analytics AB is notified before course commences.

Sartorius Stedim Data Analytics AB provides open onsite courses based on a specific number of registrants per session. Therefore, Sartorius Stedim Data Analytics AB reserves the right to cancel the course 14 days before the course start date if the number of registrants is below the minimum number needed. In the event of a cancellation, a full refund will be provided, along with a 10% discount for affected registrant(s) to enroll in the next available course.