One of the most requested parameters in industrial cell cultivation is the monitoring of biomass. The knowledge of the biomass progress during a fermentation process gives deeper process knowledge and understanding. Offline methods like visual cell counting or semi-automated systems still dominated the biomass measurement in industrial cell cultivation. But these offline methods based on taking a representative sample can not monitor the process continously. The radio frequency (RF) impedance method for online in-situ detection of viable biomass has already become well established in biopharmaceutical apllications using traditional reusable fermenter equipment. But industrial cell cultivation tends more and more to single-use (SU) fermentation solutions. BioPAT® Viamass is the first standardized online biomass measurement solution for single-use fermenter systems, which is fully integrated into the standard fermenter control system and tailored to the single-use fermantation bags such as the Flexsafe® RM and Flexsafe STR®. Integrated into the bioreactor’s DCU and Biobrain® control system, BioPAT® Viamass permits automatic monitoring and control of viable biomass.
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- Reduces the need for manual sampling, lower risk of contamination due to lower sampling needs
- Easy to use plug and play operation for rapid cell expansion
- Real-time measurement of and feedback on viable biomass
- Decreased labor and laboratory costs for offline analysis
- Ensures batch-to-batch consistency
- Improved data gathering
- Eliminates operator influence that occurs in manual biomass measurements
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