CIMmultus® C4 HLD 8000 mL cGMP Compliant Monolithic Column (6 μm)

CIMmultus^® is a unique and industry-proven line of pre-packed chromatographic monolithic columns featuring large flow-through channels, designed for working with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), virus-like particles and exosomes. CIMmultus^® columns can be used as single-use disposable or multi-use columns. They are available in a variety of volume ranges – from 1mL for screening and method development purposes to 8000mL for industrial manufacturing.

CIMmultus^® C4 HLD employs a high density of butyl ligands to achieve strong surface hydrophobicity. Relying on hydrophobic interaction chromatography (HIC), this column is a must for nucleic acid separations, providing an excellent solution for the purification of pDNA and RNA.

C4 (butyl) high ligand density (HLD) features:

• Strongly hydrophobic, uncharged
• Working range, pH 2–10
• Highly effective for removing proteins from nucleic acids (pDNA, RNA)

Your benefits:

• Very fast processes by convective mass transport
• Resolution independent of flow
• Ready to use columns
• High-capacity for large molecules due to fully accessible void volume in the channels
• Laminar flow minimizes shear stress resulting in high yields