CIMmultus® Swiper 80 mL cGMP Monolithic Column (2μm)

CIMmultus^® is a unique and industry-proven line of pre-packed chromatographic monolithic columns featuring large flow-through channels, designed for working with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), virus-like particles and exosomes. CIMmultus^® columns can be used as single-use disposable or multi-use columns. They are available in a variety of volume ranges – from 1 mL for screening and method development purposes to 8000 mL for industrial manufacturing.

The CIMmultus

Swiper is an advanced chromatography column designed for efficient nucleic acid purification within an acidic to neutral pH range. Utilizing multimodal weak anion exchanging properties, it offers exceptional selectivity between RNA, DNA, and proteins, making it ideal for complex samples. This column efficiently purifies single-stranded RNA of various sizes and modalities at neutral pH and ambient temperature, delivering optimal results without the need for extreme conditions.

Swiper features and benefits:

• Multimodal chromatography ligand that combines elements of hydrogen bonding with anion exchange chromatography
• Presents a valuable tool for various nucleic acids
• Suitable for the purification of non-polyadenylated RNA
• Tailored for sensitive and large RNA constructs, ensuring optimal performance and integrity
• Purification conducted under mild loading conditions and neutral pH elution presents a tailored purification process to meet specific research needs
• Elution by increasing pH at low conductivities facilitates the desalting of nucleic acids, ensuring enhanced purity