Filter Holder — For Sartoclear® Depth Filters and Sartobind® Membrane Adsorbers
Filter Holders are hydraulic clamping systems especially designed for the use of modular Sartoclear® Depth Filter cassettes and Sartobind® membrane chromatography cassettes. The holders are available in three standard formats for pilot scale and commercial manufacturing.
*Custom/bulk order quotes are provided within 72 hours of request.
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One platform for two technologies
Sartoclear® Depth Filters and Sartobind® membrane chromatography cassettes are two complementing technologies using the same holder and manifold plates. Use Sartoclear® Depth Filters for applications with moderate solids content. If you need large scale membrane chromatography for virus | VLP large protein capture use Sartobind® anion or cation exchangers cassettes. And to scale above 2000 L monoclonal antibody production for aggregate removal, Sartobind® Phenyl cassettes would be the right choice.
Easy handling
The filter holders are made for the use in a biopharmaceutical environment. The systems are designed for easy cleaning and ergonomic handling. The installation of varying numbers of filters is intuitive, fast and easy.
User friendly
The filter holders are equipped with easy accessible mounting bars for the quick and secure installation of commonly used accessories such as pressure sensors, pressure safety devices and bioburden reduction filters.
Applications
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Application
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Polishing
- Cell Harvest
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Polishing
Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.
The cassette design eliminates the 5 L size limitation for membrane adsorbers and offers simple pod-like modular system up to 100 L membrane volume.
Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.
The cassette design eliminates the 5 L size limitation for membrane adsorbers and offers simple pod-like modular system up to 100 L membrane volume.
Sartobind® Phenyl accomplishes polishing and capturing ten times faster than do conventional HIC resins. The membrane shows comparable, high binding capacity, without size exclusion effects, for proteins in a range of 20 mg mAb/mL membrane, as well as excellent resolution and impurity reduction.
Sartobind STIC® PA (primary amine) anion exchange membrane overcomes reduced binding capacity for host cell protein removal and can be used in high-salt conditions.
The cassette design eliminates the 5 L size limitation for membrane adsorbers and offers simple pod-like modular system up to 100 L membrane volume.
Sartobind® S membrane adsorber units combine the advantages of convective media and ion exchange chromatography for rapid and easy contaminant removal or capture of virus and virus like particles.
The cassette design eliminates the 5 L size limitation for membrane adsorbers and offers simple pod-like modular system up to 100 L membrane volume.
Sartobind® S membrane adsorber units combine the advantages of convective media and ion exchange chromatography for rapid and easy contaminant removal or capture of virus and virus like particles.
The cassette design eliminates the 5 L size limitation for membrane adsorbers and offers simple pod-like modular system up to 100 L membrane volume.
The manifold set contains the inlet and outlet adapter plates for Sartoclear® Depth Filters as well as Sartobind® membrane adsorbers cassettes.
For easy cleaning of spilled fluids
Prevents excessive pressure during compressed air draining of the filter cassettes.
For serial or parallel filtration on one layer
For easy cleaning of spilled fluids