The Resolute® BioSMB PD provides an open platform for downstream processing that enables the use of any separation technology, including packed-bed chromatography, membrane chromatography, monoliths and expanded bed adsorption (EBA) chromatography. The system is designed to convert an existing batch process into a continuous chromatography step without impacting the purification performance or product quality.Standard use cases for the Resolute® BioSMB PD include bind/elute chromatography (Protein A, affinity, ion exchange, mixed mode, hydrophobic interaction) and flow-through such as size exclusion or ion exchange polishing. The patented valve design makes the application of single-use multi-column chromatography viable by organizing all system valves into a single cassette.
