Choose your Sartobind® Rapid A
Sartobind® Rapid A capsules integrate Sartorius agarose-based membrane functionalized with Protein A ligand in a fully closed format. The available bed volumes range from 1.2 mL to 200 mL, and the performance is directly scalable between consumable sizes. Sartobind® Rapid A is engineered for time and cost-efficient mAb purification, offering competitive binding capacity (typically between 40-50 g/L1) and low pressure drop. The capsules are ready for use, and with working residence times as low as 10 seconds, the set-up and processing time can be significantly decreased. The capsule portfolio is well-suited for process development and earlier clinical-phase manufacturing.
Features and Benefits:
- Bed-height: 4 mm
- Max. operating pressure: 4 bar
- Directly scalability between formats
- Typical flow rates: 5 – 10 MV/min2
- Integrated venting valve
Applications:
- mAb purification
- Process development and early clinical stage manufacturing
- Scale-down models supporting regulatory submission (e.g. virus clearance)
1dependent on the target molecule.; 2for more information please consult Sartobind® Rapid A Instructions for Use
Application Notes
Applications
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ApplicationCapture
Compliance Information
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Biological ReactivityThe final product meets the requirements of the current ISO 10993-5 which is equivalent to the current United States Pharmacopoeia (USP) <87> Biological Reactivity Tests, in vitro.
Connections (Physical)
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Connector(s)Inlet: 1 ½" Sanitary | Outlet: 1 ½" Sanitary
Dimensions
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Bed Height4 mm
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Dimensions350 x 100 mm
Materials of Construction
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Housing MaterialPolypropylene (PP)
Operating Conditions
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Maximum Operating Pressure0.4 MPa
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Maximum Venting Pressure0.5 bar, 0.05 MPa, 7 psi
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Recommended Flow Rate3-5 MV/min (load, elution), 5-10 MV/min ( equilibration, wash)
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pH StabilitypH 2 – 14 (short term), pH 3 – 13 (long term)
Physicochemical Information
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Bed Volume200 mL
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Chemical CompatibilityStable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
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LigandProtein A
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Reference ProteinHuman polyclonal IgG
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Typical Dynamic Binding Capacity 10% per mL≥ 38 mg/mL
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Void Volume540 mL
Product Information
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BrandSartobind® Rapid A
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Membrane Adsorber FormatCapsules
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Membrane TypeAffinity
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Pack Size1
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What you receive
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1 capsule
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Operating instruction
- Certificate
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1 capsule