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Sartobind® Rapid A Capsule 200 mL

Tech Support Documents
Sartobind® Rapid A Capsule 200 mL Sartobind® Rapid A Capsule 200 mL
 

Sartobind® Rapid A capsules are a family of fully closed membrane chromatography formats designed for efficient mAb capture. The range of available sizes, directly scalable between each other, provides the necessary flexibility to accommodate different process demands.

Bed Volume
Connector(s)
Pack Size
Item No.: 
96R-PA19D1GSS
Availability: 
*Custom/bulk order quotes are provided within 72 hours of request.

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Sartobind® Rapid A capsules integrate Sartorius agarose-based membrane functionalized with Protein A ligand in a fully closed format. The available bed volumes range from 1.2 mL to 200 mL, and the performance is directly scalable between consumable sizes. Sartobind® Rapid A is engineered for time and cost-efficient mAb purification, offering competitive binding capacity (typically between 40-50 g/L1) and low pressure drop. The capsules are ready for use, and with working residence times as low as 10 seconds, the set-up and processing time can be significantly decreased. The capsule portfolio is well-suited for process development and earlier clinical-phase manufacturing.

Features and Benefits:

  • Bed-height: 4 mm
  • Max. operating pressure: 4 bar
  • Directly scalability between formats
  • Typical flow rates: 5 – 10 MV/min2
  • Integrated venting valve

Applications:

  • mAb purification
  • Process development and early clinical stage manufacturing
  • Scale-down models supporting regulatory submission (e.g. virus clearance)

1dependent on the target molecule.; 2for more information please consult Sartobind® Rapid A Instructions for Use

Applications

  • Application
    Capture

Compliance Information

  • Biological Reactivity
    The final product meets the requirements of the current ISO 10993-5 which is equivalent to the current United States Pharmacopoeia (USP) <87> Biological Reactivity Tests, in vitro.

Connections (Physical)

  • Connector(s)
    Inlet: 1 ½" Sanitary | Outlet: 1 ½" Sanitary

Dimensions

  • Bed Height
    4 mm
  • Dimensions
    350 x 100 mm

Materials of Construction

  • Housing Material
    Polypropylene (PP)

Operating Conditions

  • Maximum Operating Pressure
    0.4 MPa
  • Maximum Venting Pressure
    0.5 bar, 0.05 MPa, 7 psi
  • Recommended Flow Rate
    3-5 MV/min (load, elution), 5-10 MV/min ( equilibration, wash)
  • pH Stability
    pH 2 – 14 (short term), pH 3 – 13 (long term)

Physicochemical Information

  • Bed Volume
    200 mL
  • Chemical Compatibility
    Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
  • Ligand
    Protein A
  • Reference Protein
    Human polyclonal IgG
  • Typical Dynamic Binding Capacity 10% per mL
    ≥ 38 mg/mL
  • Void Volume
    540 mL

Product Information

  • Brand
    Sartobind® Rapid A
  • Membrane Adsorber Format
    Capsules
  • Membrane Type
    Affinity
  • Pack Size
    1
  • What you receive
    • 1 capsule
    • Operating instruction
    • Certificate
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