Sartobind® Rapid A is a protein A membrane chromatography solution engineered for efficient antibody purification in the biopharmaceutical industry, specifically designed for capturing Fc-region containing molecules. The fully scalable portfolio provides the necessary flexibility, to accelerate process development, reduce costs and increase productivity in mAb purification.

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Sartobind® Rapid A
Sartobind® Rapid A

Sartobind® Rapid A is a protein A membrane chromatography solution engineered for efficient antibody purification in the biopharmaceutical industry, specifically designed for capturing Fc-region containing molecules. The fully scalable portfolio provides the necessary flexibility, to accelerate process development, reduce costs and increase productivity in mAb purification.

Item No.:
M_Sartobind_Rapid_A

Overview

Specifications

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Sartobind® Rapid A is a protein A membrane chromatography solution designed to increase the efficiency of antibody purification processes. This platform is well-suited for process intensification, reducing process times due to higher operational flow rates, while maintaining high binding capacities and minimizing back pressure. Altogether, Sartobind® Rapid A has the potential to substantially reduce the cost associated with the mAb capture step, particularly in process development and production of material for early clinical phases.

Available formats:

  • 96 Well Plates
  • Capsules (1.2 mL, 10 mL, 75 mL and 200 mL)
  • Cassette (0.8 L)

Complementary products:

  • Rapid A Ligand
  • Manifold Pilot Holder

Features and Benefits:

  • Time Savings – faster cycling times with membranes mean less time is required for process development and validation. Moreover, column handling operations are no longer necessary.
  • Cost reduction – especially for manufacturing of clinical phase material or smaller commercial scale
  • Risk mitigation – because membranes are less sensitive to air presence or bed instability issues the risk of production stop is less significant
  • Compact footprint and flexibility- smaller bed volumes can purify the same amounts of target molecules in the same amount of time. Furthermore, there is no need for ancillary equipment related to packing and maintenance.
  • Scalability

Applications:

  • Monoclonal antibody (mAb) purification
  • Fc-region containing fusion proteins
  • Bi-specifics, multi-specific antibodies

Compliance Information

  • Biological Reactivity
    The final product meets the requirements of the current ISO 10993-5 which is equivalent to the current United States Pharmacopoeia (USP) <87> Biological Reactivity Tests, in vitro.

Dimensions

  • Bed Height
    4 mm

Operating Conditions

  • Recommended Flow Rate
    3-5 MV/min (load, elution), 5-10 MV/min (equilibration, wash)
  • pH Stability
    pH 2-14 (short term), pH 3-13 (long term)

Physicochemical Information

  • Chemical Compatibility
    Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
  • Ligand
    Protein A
  • Reference Protein
    Human polyclonal IgG
  • Typical Dynamic Binding Capacity 10% per mL
    > 38 mg/mL

Product Information

  • Brand
    Sartobind® Rapid A
  • Membrane Type
    Affinity