The cGMP In-line Lysis Tower 1000 serves as the controller unit in the system with user-friendly software. It contains four peristaltic pumps precisely controlled via ultrasonic flow sensors, ensuring tight control over process conditions. The System’s Tower also contains all safety precautions, such as non-contact pressure sensors, to allow for safe process execution.
Operating Flow Rate: 40 -500 mL/min
Compatible with:
- Single Use Lysis Reactor 1000 mL
- Single Use cGMP Lysis Reactor 1000 mL
Key Benefits:
- Continuous process, that can be coupled with filtration and capture.
- Can process up to 500 L of resuspended cells in 8h.
- State-of-the-art mixing control (low shear mixing).
- Offers precise control over NaOH exposure during cell lysis with efficient neutralisation and controlled cell debris precipitation.
- No need for chilled reagents.
- Improved robustness and contaminant removal (genomic DNA, isoform homogeneity).
- Efficient separation of debris from lysate, increasing the life span of filters used in next steps.
- Operating protocol is easily transferable from batch mode to the Sartorius In-line System.
- Low space requirements.
- cGMP compliant.
