Alkalizator - In-line Lysis System

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Alkalizator - In-line Lysis System
 

A fully automated in-line lysis system with a closed single-use loop for process development (PD) up to pilot scale. In addition to state-of-the-art mixing control, it can be configured to automatically and continuously process up to 500 L of resuspended cells per workday.

Our In-line alkaline lysis system is designed to increase control and efficiency of pDNA isolation from bacterial cells, while decreasing unwanted impurities such as host cell genomic DNA and RNA. The Lysis Reactor is a single use component with simple installation, requires little countertop space and provides a clean and simple alternative to larger batch lysis processes allowing user to use it as a plug and play combination.

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Alkalizator - In-line Lysis System
Alkalizator - In-line Lysis System

A fully automated in-line lysis system with a closed single-use loop for process development (PD) up to pilot scale. In addition to state-of-the-art mixing control, it can be configured to automatically and continuously process up to 500 L of resuspended cells per workday.

Our In-line alkaline lysis system is designed to increase control and efficiency of pDNA isolation from bacterial cells, while decreasing unwanted impurities such as host cell genomic DNA and RNA. The Lysis Reactor is a single use component with simple installation, requires little countertop space and provides a clean and simple alternative to larger batch lysis processes allowing user to use it as a plug and play combination.

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Alkalizator_In_line_Lysis_System

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A fully automated in-line lysis system with a closed single-use loop for process development (PD) up to pilot scale. In addition to state-of-the-art mixing control, it can be configured to automatically and continuously process up to 500 L of resuspended cells per workday.

Our In-line alkaline lysis system is designed to increase control and efficiency of pDNA isolation from bacterial cells, while decreasing unwanted impurities such as host cell genomic DNA and RNA. The Lysis Reactor is a single use component with simple installation, requires little countertop space and provides a clean and simple alternative to larger batch lysis processes allowing user to use it as a plug and play combination.

The Tower

The Tower serves as the controller unit in the system with user friendly software. It contains four peristaltic pumps that are precisely controlled via ultrasonic flow sensors, ensuring tight control over process conditions. The System’s Tower also contains all safety precautions, such as non-contact pressure sensors, to allow for safe process execution.

The Lysis Reactor

The Lysis Reactor is a single-use component to use in combination with the Alkalizator Tower. Together they form fully automated in-line lysis system with a closed single-use loop for process development (PD) up to pilot scale. The Lysis Reactor consists of the main reactor body with a fixed volume of 1000 mL or 5000 mL, 5 inlet paths (4 solutions and one air) and an outlet path.