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Sartobind® Rapid A 0.8 L Cassette

Tech Support Documents
Sartobind® Rapid A 0.8 L Cassette Sartobind® Rapid A 0.8 L Cassette
 

The modular concept of the Sartobind® Rapid A cassettes enables larger scale purification of mAbs, while retaining direct scalability to the capsule portfolio.

Item No.: 
98R-PA19D-L
Availability: 
*Custom/bulk order quotes are provided within 72 hours of request.

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Sartobind® Rapid A Cassettes integrate Sartorius agarose-based membrane functionalized with Protein A ligand in a stackable module. Using the Pilot Filter Holder, up to 13 cassettes can be connected, for a bed volume of up to 10.4 L. Despite the different formats, their performance is directly scalable to the capsule formats. Sartobind® Rapid A is engineered for time and cost-efficient mAb purification, offering competitive binding capacity (typically between 40-50 g/L1) and low pressure drop. With a simple and quick set-up and working residence times as low as 10 seconds, the overall processing time and costs can be significantly decreased. Sartobind® Rapid A Cassettes are well-suited for earlier clinical-phase and low-demand commercial manufacturing.

Features and Benefits:

  • Bed volume: 0.8 L/cassette
  • Bed-height: 4 mm
  • Max. operating pressure: 2 bar
  • Directly scalability to capsule formats
  • Typical flow rates: 5 – 10 MV/min2

Applications:

  • mAb purification
  • Clinical stage and lower demand commercial manufacturing

Operational Requirements:

  • Cassette Holder: Hydraulic clamping system for assembly and connection of the Sartobind® Rapid A cassettes.
  • Manifold Set: Includes the inlet and outlet plates for the Sartobind® Rapid A cassettes operation as well as the venting and draining tubing.

1dependent on the target molecule.; 2for more information please consult Sartobind® Rapid A Instructions for Use

Applications

  • Application
    Capture

Compliance Information

  • Biological Reactivity
    • The final product meets the requirements of the current ISO 10993-5 which is equivalent to the current United States Pharmacopoeia (USP) <87> Biological Reactivity Tests, in vitro.
    • All in-contact plastic components meet the requirements of current USP <88> Biological Reactivity Tests, in vivo, for Plastic Class VI (Systemic Injection, Intracutaneous and Implantation Tests).

Connections (Physical)

  • Connector(s)
    Sanitary 1" – 1.5"

Dimensions

  • Bed Height
    4 mm
  • Dimensions
    634 × 49 × 387 mm

Materials of Construction

  • Housing Material
    Acrylonitrile butadiene styrene (ABS)

Operating Conditions

  • Maximum Operating Pressure
    0.2 MPa
  • Maximum Venting Pressure
    0.5 bar, 0.05 MPa, 7 psi
  • Recommended Flow Rate
    3-5 MV/min (load, elution), 5-10 MV/min ( equilibration, wash)
  • pH Stability
    pH 2 – 14 (short term), pH 3 – 13 (long term)

Physicochemical Information

  • Bed Volume
    0.8 L
  • Chemical Compatibility
    Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
  • Ligand
    Protein A
  • Reference Protein
    Human polyclonal IgG
  • Typical Dynamic Binding Capacity 10% per mL
    ≥ 30 mg/mL
  • Void Volume
    2500 mL

Product Information

  • Brand
    Sartobind® Rapid A
  • Membrane Adsorber Format
    Cassettes
  • Membrane Type
    Affinity
  • Pack Size
    1
  • What you receive
    • 1 cassette
    • 1 operating instruction
    • 1 certificate
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