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All members of the Sartoguard family utilize a highly asymmetric polyether sulfone (PES) membrane double layer for unmatched protection of final filters and bioburden reduction with an LRV of 6 per cm². In addition, combinations with different depth filter materials and gamma sterilizable versions are available.

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Sartoguard PES
Sartoguard PES

All members of the Sartoguard family utilize a highly asymmetric polyether sulfone (PES) membrane double layer for unmatched protection of final filters and bioburden reduction with an LRV of 6 per cm². In addition, combinations with different depth filter materials and gamma sterilizable versions are available.

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M_Sartoguard_PES
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Overview

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The asymmetric polyether sulfone (PES) membranes used in Sartoguard PES filters achieve an LRV of 6 per cm². This significantly reduces the bioburden in the downstream process and protects subsequent purification steps. When used upstream of sterilization grade filters, Sartoguard PES increases overall throughput and reduces the number of filters required and process costs.

Main Applications

  • Bioburden reduction in protein- and virus-based therapies as well as in processes producing pDNA/mRNA based therapies
  • Protection of purification equipment and sterilizing-grade filters

Benefits

  • More economical process flow
  • Downsizing of filtration systems
  • Significantly higher total throughput performance
  • LRV of 6 per cm2 filtration area for Brevundimonas Diminuta (0.1 µm version) and for Serratia Marcescens (0.2 µm version)

Membrane

Sartoguard PES uses a heterogeneous double membrane made of polyethersulfone

Compatibility

Sartoguard PES Maxicaps® have been developed for sterilization using autoclaving at 134°C | 2bar.

Gamma Maxicaps® can be sterilized using either gamma or x-ray irradiation < in 50 kGy irradiation doses.

Sterilization of T-Style Maxicaps® can performed using either gamma or x-ray irradiation < in 50 kGy irradiation doses or autoclaving at 134°C | 2bar.

The Sartoguard PES polyethersulfone membrane has a high chemical compatibility between pH 1 to 14, making Sartoguard PES filters ideally suited for the filtration of high and low pH solutions in pharmaceutical | Biotech Industry.

Cost savings

Utilizing disposable filter elements removes the necessity for investing in stainless steel filter housings. This approach also eliminates additional expenses associated with housing cleaning and cleaning validation.

Flexibility

Sartoguard PES filters are available in a wide range of filtration areas from 4.5 cm² up to 1.8 m² and with a variety of commonly used connections to ensure easy integration into your process regardless of batch size.

Scalability

Consistent and predictable scale-up and scale-down procedures are ensured with Sartoguard PES filter elements, as they are all crafted using the same membrane type, support fleeces, and construction materials, providing reliability across applications.

Quality

Each element undergoes integrity testing to meet stringent quality standards, ensuring reliable performance in its applications.

Documentation

Sartoguard PES filters have been designed, developed and produced in accordance with the ISO 9001 certified quality management system. A validation manual is available in accordance with regulatory requirements.

Sterilizing grade and bioburden reduction offering

Sterilizing grade filters

  • Sartopore®: Polyethersulfone membrane
  • Sartobran® P: Cellulose acetate membrane
  • Sartolon: Polyamide membrane

Bioburden reduction filters

  • Sartoguard: Polyethersulfone membrane
  • Sartoclean®: Cellulose acetate membrane

Validation Guide

Product Information

  • Brand
    Sartoguard PES